Scientist II, WuXi AppTec, CA, US

Overview

HD Biosciences Inc., a WuXi AppTec company, offers biology-focused preclinical drug discovery services to biotech and pharmaceuticals. We offer our clients comprehensive service platforms around target validation, plate-based pharmacology, hit identification and lead discovery, in vivo pharmacology, as well as other research and development services.

We are seeking a highly motivated and skilled scientist to support our neuroscience platforms to find cures for the neurodegenerative and neuroinflammatory diseases. The successful candidate will be responsible for developing and executing advanced vitro assays using human iPSC-derived neuronal cells, primary neuronal cells, co-culture systems, and other cellular models to support drug discovery and translational neuroscience programs. This role requires strong hands-on expertise in cellular neuroscience, excellent assay development skills, and the ability to work collaboratively in a multidisciplinary environment.

Responsibilities

• Design, optimize, and execute in vitro neuroscience assays using iPSC-derived neurons, astrocytes, primary neuronal cells, and other relevant CNS cell types.• Establish and characterize co-culture models (e.g., neuron-microglia, neuron-astrocyte, or other systems). • Support projects with relevant functional readouts (neurite outgrowth, neuronal survival, high-content imaging, etc.).• Perform molecular and cellular analyses (qPCR, Flow cytometry, ELISA, imaging, etc.).• Lead and support non-neuroscience programs as needed.• Manage multiple projects, ensuring timely, accurate, and reproducible data delivery.• Prepare clear data summaries, technical reports, and presentations for internal teams and external communications.

Qualifications

Experience / Education• Ph.D. in Neuroscience, Stem Cell Biology, Cell Biology, or a related field with 4-6 years of postdoctoral or industry research experience.• Strong knowledge of neurodegenerative and neuroinflammatory diseases, including relevant cellular and molecular mechanisms.• Extensive hands-on expertise with iPSC-derived neuronal culture systems and advanced cellular neuroscience models.• Demonstrated experience developing and applying co-culture assays and functional neuronal readouts (e.g., neurite outgrowth, synaptic activity, survival assays).• Familiarity with organoid or 3D culture systems is a strong plus.• Proven ability to manage multiple projects effectively, with strong organizational and multitasking skills.• Excellent written, oral, and interpersonal communication skills.

Physical Requirements:• Must be able to work in an office environment with minimal noise conditions• Must be able to work in a lab setting with exposure to Animals/biohazards /Chemicals (List specific Chemicals) • Must not have animal allergies to applicable species in this facility. • Must be able to work in environment with variable noise levels.• Ability to stand/Sit/walk for long periods of time.• Ability to Lift 10 lbs routinely.• Ability to push/pull 10 lbs. routinely/often/occasionally• Clarity of vision.• Ability to identify and distinguish colors.• Must be able to perform activities with repetitive motions.• Ability to climb ladders/stairs/scaffolding.• Ability to work in variable temperatures high to freezing. • Inside/outside working conditions.

Anticipated base pay range: $80,322 to $95,000

An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability

This job description does not state or imply that the above are the only duties and responsibilities assigned to this position. Employees holding this position will be required to perform any other job-related duties as requested by Management.